Chai-2

OpenAI-backed Chai Discovery announced Chai-2, an AI capable of creating functional antibodies for drug development — nearing a 20% hit rate that marks a 100x improvement over methods that typically achieve less than 0.1%.

The details:

• The model designed antibodies against 52 different disease targets, finding successful treatments for half of them by testing just 20 candidates each.
• Traditional antibody discovery requires screening millions of candidates over months or years, with Chai-2 delivering results in just two weeks.
• Chai-2 works “from scratch,” creating completely new designs just by looking at a target's structure without needing any pre-existing examples.
• Chai researchers said the system is like "Photoshop for proteins," letting scientists specify exactly where antibodies should attach to disease targets.

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